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Compro rectal and Seconal Sodium

Determining the interaction of Compro rectal and Seconal Sodium and the possibility of their joint administration.

Check result:

Compro rectal <> Seconal Sodium

Relevance: 09.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using prochlorperazine together with secobarbital can alter the drug levels and effects of both medications. Contact your doctor if you experience slow or shallow breathing, extreme sleepiness, hypotension or a convulsion. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant use of phenothiazines with barbiturates may reduce the plasma concentrations and therapeutic effects of both agents. The mechanism is unclear but may relate to metabolic induction of CYP450 hepatic enzymes. In addition, coadministration of phenothiazines and barbiturates may lead to a reduction in seizure threshold and additive central nervous system (CNS) and respiratory depressant effects.

MANAGEMENT: Administration of phenothiazines in patients receiving large doses of barbiturates is considered contraindicated by some authorities (US). If coadministration is required, caution as well as clinical and laboratory monitoring should be considered whenever either of these agents is added to or withdrawn from therapy. If chlorpromazine is coadministered with a barbiturate, the manufacturer of chlorpromazine recommends using 1/4 to 1/2 of the usual barbiturate dosage. Patients should be monitored for hypotension, loss of seizure control and the development of adverse effects including CNS and respiratory depression.

References

"Product Information. FluPHENAZine Decanoate (fluPHENAZine (fluphenazine))." Mylan Institutional LLC, Rockford, IL.
"Product Information. Thioridazine Hydrochloride (thioridazine)." Mylan Institutional (formerly UDL Laboratories), Rockford, IL.
Harashima H, Sugiyama Y, Sawada Y, Shigenobu K, Kasuya Y, Iga T, Hanano M "Kinetic analysis of the positive inotropic action (PIA) of ouabain in isolated perfused rabbit heart. Slow onset of PIA and slow binding to Na+, K+-adenosine triphosphatase." J Pharmacobiodyn 11 (1988): 533-40
Forrest FM, Forrest IS, Serra MT "Modification of chlorpromazine metabolism by some other drugs frequently administered to psychiatric patients." Biol Psychiatry 2 (1970): 53-8
Linnoila M, Viukari M, Vaisanen K, Auvinen J "Effect of anticonvulsants on plasma haloperidol and thioridazine levels." Am J Psychiatry 137 (1980): 819-21
Ellenor GL, Musa MN, Beuthin FC "Phenobarbital--thioridazine interaction in man." Res Commun Chem Pathol Pharmacol 21 (1978): 185-8
Dundee JW, Moore J "The effects of premedication with phenothiazine derivatives on the course of methohexitone anaesthesia." Br J Anaesth 33 (1961): 382-96
Ellenor GL, Musa MN, Beuthin FC "Phenobarbital-thioridazine interaction in man." Res Commun Chem Pathol Pharmacol 21 (1978): 185-8
"Product Information. Trifluoperazine Hydrochloride (trifluoperazine)." Mylan Institutional (formerly UDL Laboratories), Rockford, IL.
"Product Information. Perphenazine (perphenazine)." Actavis Pharma, Inc., Parsippany, NJ.
Gay PE, Madsen JA "Interaction between phenobarbital and thioridazine." Neurology 33 (1983): 1631-2

Compro rectal

Generic Name: prochlorperazine

Brand name: Compro, Compazine

Synonyms: Compro (rectal), Compro

What is Compro rectal?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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