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Comtrex Flu Therapy Day/Night and Levodopa (Oral Inhalation)

Determining the interaction of Comtrex Flu Therapy Day/Night and Levodopa (Oral Inhalation) and the possibility of their joint administration.

Check result:
Comtrex Flu Therapy Day/Night <> Levodopa (Oral Inhalation)
Relevance: 13.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Both levodopa and phenylephrine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with levodopa may potentiate the cardiovascular effects of sympathomimetic agents (e.g., epinephrine, norepinephrine, isoproterenol, amphetamine). Additive increases in blood pressure and heart rate may occur due to enhanced sympathetic activity. However, data evaluating the interaction are not available.

MANAGEMENT: The use of levodopa with sympathomimetic agents should generally be avoided. If concomitant use is required, close monitoring of the cardiovascular system is recommended and the dose of the sympathomimetic agent may need to be reduced.

References
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Comtrex Flu Therapy Day/Night

Generic Name: acetaminophen / chlorpheniramine / phenylephrine

Brand name: Allergy Multi-Symptom, Allergy Multi-Symptom Daytime, Comtrex Flu Therapy Day/Night, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Gendecon, Protid, Dryphen, Comtrex Flu Therapy, Sinus Congestion & Pain Nighttime, Allergy Relief Multi-Symptom, Tylenol Sinus Congestion-Pain Cool Burst, Relief-PE, Contact Cold and Flu Night, Cold Relief Plus, EQL Effervescent Plus Cold, GNP Cold Relief Plus, QC Cold Relief Plus

Synonyms: n.a.

Levodopa (Oral Inhalation)

Generic Name: levodopa

Brand name: Inbrija, Dopar, Larodopa

Synonyms: Levodopa inhalation

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.