Conestat alfa and Inotersen Subcutaneous

• Generic Name: conestat alfa
• Dosage Forms: n.a.
• Other Brand Names: Ruconest

Conestat alfa is a manmade form of a protein called C1 esterase inhibitor that occurs naturally in the bloodstream and helps control swelling in the body. People with a condition called hereditary angioedema do not have enough of this protein. Hereditary angioedema can cause attacks of swelling and symptoms such as stomach problems or trouble breathing.

Conestat alfa is used to treat angioedema attacks in people with hereditary angioedema. Conestat alfa is for use in adults and children who are at least 13 years old.

Conestat alfa may also be used for purposes not listed in this medication guide.

• Generic Name: inotersen
• Dosage Forms: n.a.
• Other Brand Names: Tegsedi

Inotersen injection is used to treat polyneuropathy (nerve disease) of hereditary transthyretin-mediated amyloidosis.

Inotersen is available only under a restricted distribution program called Tegsedi™ REMS (Risk Evaluation and Mitigation Strategy) Program.