Conivaptan Intravenous and Leuprolide and norethindrone
Determining the interaction of Conivaptan Intravenous and Leuprolide and norethindrone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Conivaptan may increase the blood levels and effects of norethindrone, even after you have stopped using conivaptan for a while. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with conivaptan may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by conivaptan. In pharmacokinetic studies with drugs that are primarily metabolized by CYP450 3A4 such as midazolam, simvastatin, and amlodipine, conivaptan has increased systemic exposure (AUC) by 2- to 3-fold.
MANAGEMENT: Caution is advised if conivaptan must be used concurrently with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever conivaptan is added to or withdrawn from therapy, or the combination avoided altogether. If a clinical decision is made to discontinue concomitant medications at recommended doses, clinicians should allow an appropriate amount of time following the end of conivaptan administration before resuming these medications.
- "Product Information. Vaprisol (conivaptan)." Cumberland Pharmaceuticals Inc, Nashville, TN.
Generic Name: conivaptan
Brand name: Vaprisol
Synonyms: Conivaptan
Generic Name: leuprolide / norethindrone
Brand name: Lupaneta Pack
Synonyms: Leuprolide and Norethindrone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Conivaptan Intravenous-Leuprolide and norethindrone Intramuscular, Oral
- Conivaptan Intravenous-Leuprolide Injection (CPP)
- Conivaptan Intravenous-Leuprolide Injection (Prostate)
- Conivaptan Intravenous-Leuprolide Injection (Women)
- Conivaptan Intravenous-Leuprolide Intramuscular, Subcutaneous, Intradermal, Injection
- Conivaptan Intravenous-Leustatin
- Leuprolide and norethindrone-Conjugated estrogens
- Leuprolide and norethindrone-Conjugated estrogens and bazedoxifene
- Leuprolide and norethindrone-Conjugated estrogens and medroxyprogesterone
- Leuprolide and norethindrone-Conjugated estrogens and medroxyprogesterone Oral
- Leuprolide and norethindrone-Conjugated Estrogens Injection
- Leuprolide and norethindrone-Conjugated estrogens Intravenous