Conjugated estrogens and medroxyprogesterone Oral and Tamoxifen Solution
Determining the interaction of Conjugated estrogens and medroxyprogesterone Oral and Tamoxifen Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that concomitant administration of medroxyprogesterone may reduce N-demethylation of tamoxifen, but that overall metabolism remains unchanged. The mechanism and the clinical significance of this interaction are unknown.
- Reid AD, Horobin JM, Newman EL, Preece PE "Tamoxifen metabolism is altered by simultaneous administration of medroxyprogesterone acetate in breast cancer patients." Breast Cancer Res Treat 22 (1992): 153-6
Generic Name: conjugated estrogens / medroxyprogesterone
Brand name: Premphase, Prempro
Synonyms: Conjugated estrogens and medroxyprogesterone, Estrogens (Conjugated/Equine) and Medroxyprogesterone
Generic Name: tamoxifen
Brand name: Soltamox, Nolvadex
Synonyms: Tamoxifen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Conjugated estrogens and medroxyprogesterone Oral-Tamoxifen Tablets
- Conjugated estrogens and medroxyprogesterone Oral-Tamsulosin
- Conjugated estrogens and medroxyprogesterone Oral-Tamsulosin Capsules
- Conjugated estrogens and medroxyprogesterone Oral-Tamsulosin Hydrochloride
- Conjugated estrogens and medroxyprogesterone Oral-Tandem
- Conjugated estrogens and medroxyprogesterone Oral-Tandem Capsules
- Tamoxifen Solution-Conjugated Estrogens Injection
- Tamoxifen Solution-Conjugated estrogens Intravenous
- Tamoxifen Solution-Conjugated estrogens synthetic a
- Tamoxifen Solution-Conjugated estrogens synthetic b
- Tamoxifen Solution-Conjugated Estrogens Tablets
- Tamoxifen Solution-Conjugated estrogens vaginal