Copiktra and Cyclobenzaprine Capsules
Determining the interaction of Copiktra and Cyclobenzaprine Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Duvelisib may increase the blood levels and effects of cyclobenzaprine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with duvelisib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 3A4 by duvelisib. The interaction may be particularly important for sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index. When a single 2 mg oral dose of midazolam, a sensitive CYP450 3A4 substrate, was administered to 14 healthy adult study subjects following multiple doses of duvelisib 25 mg twice daily for 5 days, midazolam peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.2- and 4.3-fold, respectively.
MANAGEMENT: Caution is advised if duvelisib is used in combination with sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index (e.g., ergot alkaloids, colchicine, fentanyl, macrolide immunosuppressants, midazolam, triazolam, vinca alkaloids). Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever duvelisib is added to or withdrawn from therapy.
- "Product Information. Copiktra (duvelisib)." Verastem, Inc., Needham, MA.
Generic Name: cyclobenzaprine
Brand name: Amrix, Comfort Pac with Cyclobenzaprine, Fexmid, Flexeril
Synonyms: Cyclobenzaprine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Copiktra-Cyclobenzaprine Extended-Release Capsules
- Copiktra-Cyclobenzaprine Tablets
- Copiktra-Cyclocort
- Copiktra-Cyclocort (Amcinonide Cream and Ointment)
- Copiktra-Cyclocort (Amcinonide Lotion)
- Copiktra-Cyclocort Cream
- Cyclobenzaprine Capsules-CoQ10 coenzyme Q-10
- Cyclobenzaprine Capsules-Coral Calcium
- Cyclobenzaprine Capsules-Cordarone
- Cyclobenzaprine Capsules-Cordarone injection
- Cyclobenzaprine Capsules-Cordarone IV Intravenous
- Cyclobenzaprine Capsules-Cordran