Copiktra and Robitussin Maximum Strength (Dextromethorphan Liquid and Syrup)
Determining the interaction of Copiktra and Robitussin Maximum Strength (Dextromethorphan Liquid and Syrup) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Duvelisib may increase the blood levels and effects of dextromethorphan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with duvelisib may increase the plasma concentrations of drugs that are primarily metabolized by the CYP450 3A4 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 3A4 by duvelisib. The interaction may be particularly important for sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index. When a single 2 mg oral dose of midazolam, a sensitive CYP450 3A4 substrate, was administered to 14 healthy adult study subjects following multiple doses of duvelisib 25 mg twice daily for 5 days, midazolam peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 2.2- and 4.3-fold, respectively.
MANAGEMENT: Caution is advised if duvelisib is used in combination with sensitive CYP450 3A4 substrates or those that demonstrate a narrow therapeutic index (e.g., ergot alkaloids, colchicine, fentanyl, macrolide immunosuppressants, midazolam, triazolam, vinca alkaloids). Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever duvelisib is added to or withdrawn from therapy.
- "Product Information. Copiktra (duvelisib)." Verastem, Inc., Needham, MA.
Generic Name: dextromethorphan
Brand name: Babee Cof, Benylin DM Pediatric, Buckleys Mixture, Creomulsion, Creo-Terpin, DayQuil Cough, Delsym, Delsym 12 Hour Cough Relief, Elixsure Cough, Robafen Cough Liquidgels, Robitussin CoughGels, Scot-Tussin Diabetic, Silphen DM, St. Joseph Cough Suppressant, Sucrets DM Cough, Theraflu Thin Strips Cough, Triaminic Long Acting Cough, DexAlone, Hold, Sucrets 4-Hour Cough Drops, Robitussin Maximum Strength, Vicks Formula 44
Synonyms: Dextromethorphan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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