Copiktra and Zykadia
Determining the interaction of Copiktra and Zykadia and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.ADJUST DOSE: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of duvelisib, which is primarily metabolized by the isoenzyme. When a single 10 mg oral dose of duvelisib was coadministered with the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 5 days) in 16 healthy study subjects, duvelisib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.7- and 4-fold, respectively. Based on physiologically-based pharmacokinetic (PBPK) modeling and simulation, the increase in duvelisib exposure is estimated to be approximately 2-fold at steady state during coadministration with potent CYP450 3A4 inhibitors. MANAGEMENT: The dosage of duvelisib should be reduced to 15 mg twice daily when used with potent CYP450 3A4 inhibitors. Patients should be closely monitored for the development of toxicities such as diarrhea, colitis, neutropenia, thrombocytopenia, pneumonitis, infections, cutaneous reactions and hepatotoxicity, and the dosing adjusted or discontinued in accordance with the duvelisib product labeling. References "Product Information. Copiktra (duvelisib)." Verastem, Inc., Needham, MA.
Professional:ADJUST DOSE: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of duvelisib, which is primarily metabolized by the isoenzyme. When a single 10 mg oral dose of duvelisib was coadministered with the potent CYP450 3A4 inhibitor ketoconazole (200 mg twice daily for 5 days) in 16 healthy study subjects, duvelisib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.7- and 4-fold, respectively. Based on physiologically-based pharmacokinetic (PBPK) modeling and simulation, the increase in duvelisib exposure is estimated to be approximately 2-fold at steady state during coadministration with potent CYP450 3A4 inhibitors.
MANAGEMENT: The dosage of duvelisib should be reduced to 15 mg twice daily when used with potent CYP450 3A4 inhibitors. Patients should be closely monitored for the development of toxicities such as diarrhea, colitis, neutropenia, thrombocytopenia, pneumonitis, infections, cutaneous reactions and hepatotoxicity, and the dosing adjusted or discontinued in accordance with the duvelisib product labeling.
- "Product Information. Copiktra (duvelisib)." Verastem, Inc., Needham, MA.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.