Cordarone and Dorzolamide and Timolol
Determining the interaction of Cordarone and Dorzolamide and Timolol and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using amiodarone together with timolol ophthalmic may lead to increased side effects. Contact your doctor if you experience a reduced heart rate, dizziness, fainting, or headaches. You may need a dose adjustment or need your blood pressure checked more often if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Additive effects of severe bradycardia, cardiac arrest, and ventricular fibrillation may occur in patients administered amiodarone and beta blockers. The mechanism may be related to additive slowing in AV conduction. In addition, amiodarone may inhibit the first pass hepatic metabolism of some beta blockers. However, a post hoc meta analysis suggests that the addition of amiodarone in patients in whom it is indicated, who are recovering from a recent myocardial infarction, and who are already receiving beta-blockers decreases the incidence of cardiac or arrhythmic death.
MANAGEMENT: Clinical monitoring of patient hemodynamic status and response is recommended.
- Warren R, Vohra J, Hunt D, Hamer A "Serious interactions of sotalol with amiodarone and flecainide." Med J Aust 152 (1990): 277
- Ogunyankin KO, Singh BN "Mortality reduction by antiadrenergic modulation of arrhythmogenic substrate: Significance of combining beta blockers and amiodarone." Am J Cardiol 84 (1999): r76-82
- Boutitie F, Boissel JP, Connolly SJ, et al "Amiodarone interaction with beta-blockers - Analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases." Circulation 99 (1999): 2268-75
- Leor J, Levartowsky D, Sharon C, Farfel Z "Amiodarone and beta-adrenergic blockers: an interaction with metoprolol but not with atenolol." Am Heart J 16 (1988): 206-7
Generic Name: amiodarone
Brand name: Cordarone, Pacerone, Nexterone
Synonyms: n.a.
Generic Name: dorzolamide / timolol ophthalmic
Brand name: Cosopt, Cosopt PF
Synonyms: Dorzolamide and timolol ophthalmic
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cordarone-Dorzolamide and Timolol Eye Drops
- Cordarone-Dorzolamide and timolol ophthalmic
- Cordarone-Dorzolamide and Timolol Ophthalmic Solution
- Cordarone-Dorzolamide and Timolol Preservative-Free Eye Drops
- Cordarone-Dorzolamide Hydrochloride
- Cordarone-Dorzolamide ophthalmic
- Dorzolamide and Timolol-Cordarone injection
- Dorzolamide and Timolol-Cordarone IV Intravenous
- Dorzolamide and Timolol-Cordran
- Dorzolamide and Timolol-Cordran (Flurandrenolide Cream and Ointment)
- Dorzolamide and Timolol-Cordran (Flurandrenolide Lotion)
- Dorzolamide and Timolol-Cordran Lotion