Cordarone and Scandonest

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amiodarone together with mepivacaine can affect the rhythm of your heart. Contact your doctor if you experience dizziness, weakness, headache, difficulty breathing, and an irregular heartbeat. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Amide-type local anesthetics may have additive cardiac effects (e.g., bradycardia, chest pain, heart block, arrhythmias, ECG abnormalities, cardiac arrest) with class III antiarrhythmic agents. Although specific trials studying the interaction have not been performed, a case report suggests additive depressive effects of amiodarone and lidocaine on the sinoatrial node. A 64-year-old man with sick sinus syndrome developed severe, symptomatic sinus bradycardia and sinoatrial arrest following local anesthesia with lidocaine while he was on amiodarone therapy. No other cause was identified.

MANAGEMENT: Patients treated with class III antiarrhythmic agents (e.g., amiodarone, dofetilide, ibutilide, sotalol) should be under close surveillance during administration of amide-type local anesthetics. ECG monitoring should be considered.

Cordarone

Generic Name: amiodarone

Brand name: Cordarone, Pacerone, Nexterone

Synonyms: n.a.

What is Cordarone?

Scandonest

Generic Name: mepivacaine

Brand name: Carbocaine HCl, Polocaine, Polocaine-MPF, Scandonest, Carbocaine, Polocaine DENTAL, Carbocaine 2% with Neo-Cobefrin, Polocaine Dental, Scandonest 2% L, Carbocaine Preservative-Free, Scandonest 3% Plain

Synonyms: Mepivacaine

What is Scandonest?