Cordarone injection and Neoral

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amiodarone together with cycloSPORINE can increase the effects of cycloSPORINE, which can cause damage to the kidneys or cause nerve loss. Tell your doctor if you experience dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. Talk with your doctor if you develop fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with amiodarone may significantly increase the blood concentrations of cyclosporine. The risk of nephro- and neurotoxicity associated with cyclosporine may be increased. The proposed mechanism is amiodarone inhibition of CYP450 3A4, the isoenzyme responsible for the intestinal and hepatic metabolism of cyclosporine. Enhanced cyclosporine oral bioavailability due to inhibition of intestinal P-glycoprotein efflux transporters may also contribute. In one report, eight transplant patients demonstrated a 31% increase in serum cyclosporine levels following the administration of amiodarone for atrial flutter or atrial fibrillation, despite a 44% reduction in the cyclosporine dosage. Increases in serum creatinine were observed. There have also been case reports of transplant patients stabilized on cyclosporine who developed nephrotoxicity and/or elevated blood levels of cyclosporine following the addition of amiodarone. In one case, cyclosporine blood levels increased more than twofold, and in another, cyclosporine clearance decreased by more than 50%. Significant dosage reductions were required. Due to the long half-lives of amiodarone and its pharmacologically active desethyl metabolite, the interaction may be observed for weeks following discontinuation of amiodarone.

MANAGEMENT: Caution is advised if cyclosporine is used in combination with amiodarone. Cyclosporine blood levels and renal function should be checked frequently and the dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of amiodarone in patients who are stabilized on their cyclosporine regimen. Patients should be advised to notify their physician if they experience possible signs of cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions.

Cordarone injection

Generic Name: amiodarone

Brand name: Cordarone, Pacerone, Nexterone

Synonyms: Cordarone

What is Cordarone injection?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?