Cordarone injection and Quinidex Extentabs

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amiodarone together with quiNIDine may occasionally worsen your heart condition or cause serious heart rhythm disturbances. In addition, amiodarone can increase the blood levels and effects of quiNIDine. This can occur even after you have stopped taking amiodarone for a while because the drug stays in the body for a prolonged period. You may need a dose adjustment if you have been taking quiNIDine and are starting treatment with amiodarone. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, headache, nausea, vomiting, diarrhea, ringing in the ear, hearing loss, vision abnormalities, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of amiodarone and quinidine may increase the risk of new arrhythmias due to additive depressant effects on cardiac conduction. There have been reports of torsade de pointes arrhythmia in association with significantly prolonged QT interval in patients receiving concomitant therapy. Serious exacerbation of preexisting arrhythmia may also be more likely during coadministration relative to either agent alone. Despite the potential toxicities, amiodarone and quinidine have been used together successfully in the treatment of certain arrhythmias.

ADJUST DOSE: Amiodarone may increase the plasma concentrations of quinidine. The mechanism of interaction has not been established, but may involve inhibition of quinidine clearance via CYP450 3A4 metabolism and/or P-glycoprotein efflux. In 11 patients stabilized on quinidine (1.2 to 4.2 gm/day), the addition of amiodarone (600 mg every 12 hours for 5 to 7 days, followed by 600 mg daily) increased mean serum quinidine concentrations by approximately 33%. Signs of toxicity including diarrhea, nausea, vomiting, and hypotension were reported in some patients, necessitating dosage reductions by an average of 37%. Due to the long and variable half-life of amiodarone, potential for interaction may exist even after its discontinuation.

MANAGEMENT: The concurrent use of amiodarone with other antiarrhythmic agents, including quinidine, should be reserved for patients with life-threatening ventricular arrhythmias who are incompletely responsive to a single agent or to amiodarone alone. A dosage reduction for quinidine is recommended during coadministration. In general, if adding or transferring to oral amiodarone, the dosages of previously administered agents should be reduced by 30% to 50% several days after initiation of amiodarone, when onset of arrhythmia suppression is expected to occur. The continued need for other antiarrhythmic agents should be evaluated after the effects of amiodarone have been established, and discontinuation should ordinarily be attempted. If the combination is continued, patients should be monitored closely for adverse effects including conduction disturbances and exacerbation of tachyarrhythmias. Conversely, in amiodarone-treated patients who require additional antiarrhythmic agents, the initial dosage of such agents should be approximately one-half the usual recommended dosage. Patients should be advised to seek medical attention if they experience potential signs of quinidine toxicity such as nausea, vomiting, diarrhea, tinnitus, hearing loss, vertigo, visual disturbances, dizziness, headache and confusion, or symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitations, irregular heartbeat, shortness of breath and syncope.

Cordarone injection

Generic Name: amiodarone

Brand name: Cordarone, Pacerone, Nexterone

Synonyms: Cordarone

What is Cordarone injection?

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?