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Cordarone injection and Verelan PM

Determining the interaction of Cordarone injection and Verelan PM and the possibility of their joint administration.

Check result:

Cordarone injection <> Verelan PM

Relevance: 06.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

The use of amiodarone with verapamil may have additive effects when taken together. While this combination may be useful in some situations contact your doctor if you have a reduced heart rate, dizziness, fainting, or headaches. Your blood pressure may need to be checked more frequently. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR CLOSELY: Amiodarone and diltiazem or verapamil may have additive pharmacodynamic effects when administered concurrently. Sinus arrest, reduced myocardial contractility, and hypotension could result.

MANAGEMENT: The patient's hemodynamic and electrocardiographic status should be closely monitored, especially during amiodarone loading.

References

Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23
Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71
Lee TH, Friedman PL, Goldman L, Stone PH, Antman EM "Sinus arrest and hypotension with combined amiodarone-diltiazem therapy." Am Heart J 109 (1985): 163-4
Lee TH, Friedman PL, Goldman L, Stone PH, Antman EM "Sinus arrest and hypotension with combined amiodarone-diltiazem therapy." Am Heart J 109 (1985): 163-4

Cordarone injection

Generic Name: amiodarone

Brand name: Cordarone, Pacerone, Nexterone

Synonyms: Cordarone

What is Cordarone injection?

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

What is Verelan PM?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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