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Cordarone injection and Xenical

Determining the interaction of Cordarone injection and Xenical and the possibility of their joint administration.

Check result:

Cordarone injection <> Xenical

Relevance: 06.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Orlistat may reduce the blood levels of amiodarone, which may make the medication less effective in treating your condition. Contact your doctor if your symptoms worsen or your condition changes. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Orlistat may reduce the bioavailability of oral amiodarone and its active metabolite, N-desethylamiodarone. The proposed mechanism is alteration of the gastrointestinal lipid phase due to inhibition of dietary fat absorption by orlistat, which may decrease the absorption of highly lipophilic drugs. When a single 1200 mg dose of amiodarone was administered to healthy study subjects following treatment with orlistat 120 mg three times daily for 13 days, systemic exposure to amiodarone and N-desethylamiodarone decreased by 23% to 27%. The effect of initiating orlistat treatment in patients on stable amiodarone therapy has not been studied.

MANAGEMENT: Caution is advised when amiodarone is used with orlistat. The possibility of diminished therapeutic effects of amiodarone should be considered. Patients should be monitored more closely following the addition or withdrawal of orlistat, and the amiodarone dosage adjusted as needed.

References

"Product Information. Xenical (orlistat)." Roche Laboratories, Nutley, NJ.
Zhi J, Moore R, Kanitra L, Mulligan TE "Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers." J Clin Pharmacol 43 (2003): 428-35

Cordarone injection

Generic Name: amiodarone

Brand name: Cordarone, Pacerone, Nexterone

Synonyms: Cordarone

What is Cordarone injection?

Xenical

Generic Name: orlistat

Brand name: Alli, Xenical, Alli

Synonyms: n.a.

What is Xenical?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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