Cordarone IV Intravenous and Lorazepam Oral Concentrate
Determining the interaction of Cordarone IV Intravenous and Lorazepam Oral Concentrate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Amiodarone may increase the pharmacologic effect of benzodiazepines by its adrenergic blocking effects. Data are available for diazepam. Management consists of monitoring the patient's mental status during coadministration.
- Wilson JS, Podrid PJ "Side effects from amiodarone." Am Heart J 121 (1991): 158-71
- Nolan PE, Marcus FI, Karol MD, Hoyer GL, Gear K "Effect of phenytoin on the clinical pharmacokinetics of amiodarone." J Clin Pharmacol 30 (1990): 1112-9
- "Product Information. Xanax XR (alprazolam)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
- Kerin NZ, Aragon E, Faitel K, Frumin H, Rubenfire M "Long-term efficacy and toxicity of high- and low-dose amiodarone regimens." J Clin Pharmacol 29 (1989): 418-23
- "Product Information. Niravam (alprazolam)." Schwarz Pharma, Mequon, WI.
- "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
Generic Name: amiodarone
Brand name: Pacerone, Cordarone, Nexterone
Synonyms: Cordarone IV (Intravenous)
Generic Name: lorazepam
Brand name: Ativan, Lorazepam Intensol
Synonyms: Lorazepam, LORazepam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cordarone IV Intravenous-Lorazepam Oral Solution
- Cordarone IV Intravenous-Lorazepam Tablets
- Cordarone IV Intravenous-Lorbrena
- Cordarone IV Intravenous-Lorcaserin
- Cordarone IV Intravenous-Lorcaserin Extended-Release Tablets
- Cordarone IV Intravenous-Lorcaserin Hydrochloride
- Lorazepam Oral Concentrate-Cordran
- Lorazepam Oral Concentrate-Cordran (Flurandrenolide Cream and Ointment)
- Lorazepam Oral Concentrate-Cordran (Flurandrenolide Lotion)
- Lorazepam Oral Concentrate-Cordran Lotion
- Lorazepam Oral Concentrate-Cordran SP
- Lorazepam Oral Concentrate-Cordran Tape