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Coreg CR and Fluconazole Intravenous

Determining the interaction of Coreg CR and Fluconazole Intravenous and the possibility of their joint administration.

Check result:

Coreg CR <> Fluconazole Intravenous

Relevance: 16.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carvedilol together with fluconazole may increase the effects of carvedilol. Contact your doctor if you experience slow heartbeat, low blood pressure, swelling, headaches, dizziness, or feeling like you might pass out. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Fluconazole may increase serum levels of carvedilol. The mechanism is inhibition of CYP450 2C9, one of the isoenzymes involved in the metabolism of carvedilol. Further reductions in heart rate or cardiac conduction may occur.

MANAGEMENT: Patients should be monitored for signs of increased carvedilol effects, such as bradycardia or heart block.

References

"Product Information. Coreg (carvedilol)." SmithKline Beecham, Philadelphia, PA.

Coreg CR

Generic Name: carvedilol

Brand name: Coreg, Coreg CR

Synonyms: n.a.

What is Coreg CR?

Fluconazole Intravenous

Generic Name: fluconazole

Brand name: Diflucan

Synonyms: Fluconazole

What is Fluconazole Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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