Coricidin HBP Day/Night Cold and Interferon Gamma

• Generic Name: acetaminophen / chlorpheniramine / dextromethorphan / guaifenesin
• Dosage Forms: n.a.
• Other Brand Names: Coricidin HBP Day/Night Cold

• It is used to ease allergy signs.
• It is used to thin mucus so it can be taken from the body by coughing.
• It is used to relieve coughing.
• It is used to ease pain and fever.

• Generic Name: interferon gamma-1b
• Dosage Forms: n.a.
• Other Brand Names: Actimmune

Reduction of the frequency and severity of serious infections in patients with chronic granulomatous disease (designated an orphan drug by FDA for this use).

Treatment to delay the time to disease progression in patients with severe, malignant osteopetrosis (designated an orphan drug by FDA for this use).

Interferon gamma-1b was investigated in patients with idiopathic pulmonary fibrosis (IPF) with mild-to-moderate lung function impairment in the INSPIRE study; the study was terminated early when interim data analysis indicated lack of benefit in patients receiving the drug. Interim analysis also indicated that 14.5% of patients receiving interferon gamma 1-b died compared with 12.7% of those receiving placebo.

Interferon gamma-1b is not approved for use in patients with IPF. FDA suggests that health-care professionals should discuss the results of this trial with their patients receiving the drug for IPF and carefully consider whether they should continue to receive treatment with interferon gamma-1b.