Corlanor (Ivabradine Tablets) and Rectiv topical

• Generic Name: ivabradine
• Dosage Forms: tablet, film coated
• Other Brand Names: Corlanor

• It is used to treat heart failure (weak heart).
• It is used in certain patients with heart failure to lower the chance of having to go to the hospital for heart failure that gets worse.
• It may be given to you for other reasons. Talk with the doctor.

• Generic Name: nitroglycerin
• Dosage Forms: rectal ointment
• Other Brand Names: Rectiv, Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit

Intra-anal treatment of moderate to severe pain associated with chronic anal fissure.

Chronic anal fissure is thought to be related to sustained high resting anal sphincter tone and associated anodermal ischemia. Lateral internal sphincterotomy generally has been used to treat anal fissures that do not respond to conservative therapy (e.g., sitz baths, increased dietary fiber); however, minor incontinence, which may be persistent, may develop after surgery. Botulinum toxin type A injections or topical therapy with nitrates (e.g., nitroglycerin rectal ointment) or calcium-channel blocking agents (e.g., diltiazem gel, not commercially available in US) has been used to reduce anal sphincter tone and circumvent potential complications of surgery.