Cort-Biotic and Dextromethorphan Hydrobromide and Quinidine Sulfate

• Generic Name: hydrocortisone / neomycin / polymyxin b otic
• Dosage Forms: n.a.
• Other Brand Names: Cortisporin Otic, Drotic, Masporin Otic, Cortomycin, Otocort Sterile Solution, Cortatrigen Modified, Otimar, Pediotic, AK-Spore HC Otic Suspension, Otocort Sterile Suspension, UAD Otic, Cortatrigen, Antibiotic Ear, Cort-Biotic, Oti-Sone, AK-Spore HC, Casporyn HC

Neomycin, polymyxin B, and hydrocortisone combination ear drops is used to treat infections of the ear canal and to help provide relief from redness, irritation, and discomfort of certain ear problems. It is also used to treat ear infections as a complication after ear surgery (eg, mastoidectomy, fenestration).

Neomycin and polymyxin B belong to the class of medicines known as antibiotics. They work by killing the bacteria or preventing their growth. Hydrocortisone is a steroid medicine that is used to relieve the redness, itching, and swelling caused by ear infections.

This medicine is available only with your doctor's prescription.

• Generic Name: dextromethorphan / quinidine
• Dosage Forms: n.a.
• Other Brand Names: Nuedexta

The fixed combination of dextromethorphan hydrobromide and quinidine sulfate (dextromethorphan/quinidine; Nuedexta) is used in the treatment of PBA.

PBA occurs secondary to various otherwise unrelated neurologic conditions (e.g., amyotrophic lateral sclerosis [ALS], multiple sclerosis [MS], dementia of the Alzheimer's type [Alzheimer's disease] or other dementia, parkinsonian syndrome, stroke, traumatic brain injury) and is characterized by involuntary, sudden, uncontrollable, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state.

Studies supporting efficacy in PBA were conducted in patients with underlying ALS or MS.

Safety and efficacy in the treatment of other common types of emotional lability (e.g., those occurring in patients with Alzheimer's disease and other dementias) not established.