Corticorelin ovine triflutate and Dynacirc CR
Determining the interaction of Corticorelin ovine triflutate and Dynacirc CR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Corticorelin may reduce the effects of isradipine in lowering blood pressure. The interaction is most likely to occur when corticorelin is used for more than a week, since prolonged use can cause sodium and water retention. Let your doctor know if you experience sudden, unexplained weight gain or swelling of the hands, ankles, or feet. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Corticosteroids may antagonize the effects of antihypertensive medications by inducing sodium and fluid retention. These effects may be more common with the natural corticosteroids (cortisone, hydrocortisone) because they have greater mineralocorticoid activity. Conversely, some calcium channel blockers such as diltiazem and verapamil may increase corticosteroid plasma levels and effects by inhibiting their clearance via CYP450 3A4 metabolism.
MANAGEMENT: Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment.
- "Multum Information Services, Inc. Expert Review Panel"
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: corticorelin
Brand name: Acthrel
Synonyms: n.a.
Generic Name: isradipine
Brand name: Dynacirc, Dynacirc CR
Synonyms: Dynacirc CR (Oral), DynaCirc CR
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Corticorelin ovine triflutate-Dynapen
- Corticorelin ovine triflutate-Dyphylline
- Corticorelin ovine triflutate-Dyphylline and guaifenesin
- Corticorelin ovine triflutate-Dyphylline and Guaifenesin Liquid
- Corticorelin ovine triflutate-Dyphylline and Guaifenesin Tablets
- Corticorelin ovine triflutate-Dyphylline Oral, Intramuscular
- Dynacirc CR-Corticorelin ovine triflutate Intravenous
- Dynacirc CR-Corticotropin
- Dynacirc CR-Corticotropin Injection
- Dynacirc CR-Cortifoam
- Dynacirc CR-Cortifoam foam, enema
- Dynacirc CR-Cortisone