Cortisporin Ophthalmic Suspension and Daclatasvir Dihydrochloride

• Generic Name: hydrocortisone / neomycin / polymyxin b ophthalmic
• Dosage Forms: ophthalmic suspension
• Other Brand Names:

  AK-Spore HC Ophthalmic, Cortisporin, Cortomycin Suspension, Neo/PolyB/HC

Neomycin, polymyxin B, and hydrocortisone is a combination antibiotic and cortisone-like medicine. It is used to treat infections of the eye and to help provide relief from redness, irritation, and discomfort of certain eye problems. It is also used to help prevent permanent damage of certain eye problems.

Neomycin, polymyxin B, and hydrocortisone combination is available only with your doctor's prescription.

• Generic Name: daclatasvir
• Dosage Forms: n.a.
• Other Brand Names: Daklinza

Treatment of chronic HCV genotype 1 or genotype 3 infection in treatment-naive (previously untreated) or previously treated adults, including those with cirrhosis (compensated or decompensated), liver transplant recipients, and those with HIV coinfection.

Treatment of chronic HCV genotype 2 or genotype 4 infection; only limited data available.

Must be used in conjunction with other antivirals; do not use alone.

Usually used in a multiple-drug regimen that includes sofosbuvir (with or without ribavirin).

Efficacy of daclatasvir and sofosbuvir (with or without ribavirin) for treatment of HCV genotype 1a infection is reduced in cirrhotic patients with NS5A polymorphisms M28, Q30, L31, or Y93 at baseline. Consider screening for NS5A polymorphisms prior to initiation of treatment in cirrhotic patients with HCV genotype 1a infection. (See General under Dosage and Administration.)

Efficacy of daclatasvir and sofosbuvir (with or without ribavirin) is reduced in cirrhotic patients with HCV genotype 3 infection compared with those without cirrhosis.

Treatment of chronic HCV infection is complex and rapidly evolving; consult a specialist to obtain the most up-to-date information.