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Cotolone and Taxotere

Determining the interaction of Cotolone and Taxotere and the possibility of their joint administration.

Check result:

Cotolone <> Taxotere

Relevance: 09.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Although docetaxel is a substrate of CYP450 3A4, no significant interaction has been reported with dexamethasone or prednisone, both of which are inducers of the isoenzyme. According to the product labeling, docetaxel total body clearance was not modified by pretreatment with dexamethasone. In addition, dexamethasone does not affect the protein-binding of docetaxel, which is more than 95% protein-bound. The effect of prednisone on the pharmacokinetics of docetaxel administered with standard dexamethasone premedication was studied in 42 patients. No effect on the pharmacokinetics of docetaxel was observed.

References

"Product Information. Taxotere (docetaxel)." Rhone-Poulenc Rorer, Collegeville, PA.
McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110
Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91

Cotolone

Generic Name: prednisolone

Brand name: Bubbli-Pred, Flo-Pred Oral Suspension, Hydeltrasol, Key-Pred SP, Millipred, Orapred, Orapred ODT, Pediapred, Pred-Ject-50, Predacort 50, Predalone 50, Predate-50, Veripred 20, Flo-Pred, Millipred DP, Prelone, Hydeltra-TBA, Key-Pred, Cotolone, Depo-Predate, Predicort-50, Predaject-50, Medicort, Predicort RP, Pri-Cortin 50, Predcor, AsmalPred Plus

Synonyms: Cotolone (Oral)

What is Cotolone?

Taxotere

Generic Name: docetaxel

Brand name: Taxotere, Docefrez

Synonyms: n.a.

What is Taxotere?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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