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Cotolone and Zaleplon

Determining the interaction of Cotolone and Zaleplon and the possibility of their joint administration.

Check result:

Cotolone <> Zaleplon

Relevance: 09.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Inducers of hepatic microsomal enzyme CYP450 3A4 may increase the plasma clearance of zaleplon, which is partially metabolized by this enzyme. Be aware of the possibility of reduced efficacy associated with zaleplon if these drugs are given together.

References

"Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.

Cotolone

Generic Name: prednisolone

Brand name: Bubbli-Pred, Flo-Pred Oral Suspension, Hydeltrasol, Key-Pred SP, Millipred, Orapred, Orapred ODT, Pediapred, Pred-Ject-50, Predacort 50, Predalone 50, Predate-50, Veripred 20, Flo-Pred, Millipred DP, Prelone, Hydeltra-TBA, Key-Pred, Cotolone, Depo-Predate, Predicort-50, Predaject-50, Medicort, Predicort RP, Pri-Cortin 50, Predcor, AsmalPred Plus

Synonyms: Cotolone (Oral)

What is Cotolone?

Zaleplon

Generic Name: zaleplon

Brand name: Sonata

Synonyms: n.a.

What is Zaleplon?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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