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Cotrim and Daraprim

Determining the interaction of Cotrim and Daraprim and the possibility of their joint administration.

Check result:

Cotrim <> Daraprim

Relevance: 04.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pyrimethamine together with sulfamethoxazole can increase your risk of anemias. Contact your doctor if you experience any changes in your blood test or if you feel weak or fatigued. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of pyrimethamine in doses exceeding 25 mg per week with trimethoprim or sulfonamides may increase the risk of megaloblastic anemia and pancytopenia. The proposed mechanism is additive antifolate effects.

MANAGEMENT: Periodic clinical and laboratory monitoring for signs of folic acid deficiency and hematologic changes is advisable.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Multum Information Services, Inc. Expert Review Panel"

Cotrim

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Cotrim, Septra, Sulfatrim Pediatric, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim, Bethaprim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: n.a.

What is Cotrim?

Daraprim

Generic Name: pyrimethamine

Brand name: Daraprim

Synonyms: n.a.

What is Daraprim?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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