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Coumadin and Daptomycin Intravenous

Determining the interaction of Coumadin and Daptomycin Intravenous and the possibility of their joint administration.

Check result:
Coumadin <> Daptomycin Intravenous
Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that there is no significant interaction between daptomycin and warfarin. In 16 healthy volunteers, coadministration of daptomycin (6 mg/kg once every 24 hours for 5 days) and warfarin (25 mg single oral dose) had no significant effect on the pharmacokinetics of either drug, and the INR was not significantly altered. However, given the limited nature of existing data and the high degree of interpatient variability with respect to warfarin pharmacokinetics, clinicians should consider monitoring the INR more closely for the first several days after initiating therapy with daptomycin in patients stabilized on their warfarin regimen. The same precaution is probably appropriate for other oral anticoagulants until further information is available.

References
  • "Product Information. Cubicin (daptomycin)." Cubist Pharmaceuticals Inc, Lexington, MA.
Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

Daptomycin Intravenous

Generic Name: daptomycin

Brand name: Cubicin, Cubicin RF

Synonyms: Daptomycin, DAPTOmycin

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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