Coumadin and Darvocet

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using propoxyphene together with warfarin can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Case reports have suggested that propoxyphene may increase the hypoprothrombinemic effects of warfarin. Bleeding episodes have been reported. However, causality is unclear because a propoxyphene/acetaminophen combination product was involved. Controlled studies have not demonstrated an interaction between propoxyphene and warfarin. The mechanism is unknown.

MANAGEMENT: Until more information is available, if propoxyphene and an anticoagulant must be used together, observation for altered anticoagulant effect is indicated. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Darvocet

Generic Name: acetaminophen / propoxyphene

Brand name: Balacet, Darvocet, Propacet 100

Synonyms: Darvocet-N

What is Darvocet?