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Coumadin and Defibrotide

Determining the interaction of Coumadin and Defibrotide and the possibility of their joint administration.

Check result:

Coumadin <> Defibrotide

Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using defibrotide together with warfarin is not recommended. Combining these medications may increase the risk of bleeding. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need to wait until the effects of one drug has worn off before starting the other. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Coadministration of defibrotide with anticoagulants may increase the risk of bleeding. In vitro, defibrotide increased the activity of fibrinolytic enzymes; therefore, it may enhance the pharmacologic effects of antithrombotic agents.

MANAGEMENT: Concomitant use of defibrotide with systemic anticoagulants (except for routine maintenance or reopening of central venous lines) is considered contraindicated. Anticoagulants should be discontinued prior to initiation of defibrotide. Preferably, defibrotide administration should be delayed until the effects of anticoagulant therapy have subsided. Some authorities recommend avoiding use of anticoagulants within 24 hours of defibrotide administration, or within 12 hours in the case of unfractionated heparin. Patients should be monitored for signs of bleeding during defibrotide therapy. If bleeding develops, defibrotide should be discontinued and treatment/supportive care provided until the bleeding stops.

References

"Product Information. Defitelio (defibrotide)." Jazz Pharmaceuticals, Palo Alto, CA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Defibrotide

Generic Name: defibrotide

Brand name: Defitelio

Synonyms: Defibrotide Sodium

What is Defibrotide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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