Coumadin and Dipyridamole Oral, Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dipyridamole together with warfarin can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Although dipyridamole is often used in combination with oral anticoagulants in clinical practice, the potential for an increased risk of bleeding should be considered during coadministration. In general, dipyridamole does not appear to significantly alter prothrombin time or increase bleeding compared to warfarin alone. However, there have been isolated reports of enhanced hypoprothrombinemic response to warfarin in the presence of dipyridamole, or increased warfarin requirement following discontinuation of dipyridamole. The mechanism of interaction is unknown.

MANAGEMENT: Monitoring for signs of increased anticoagulation and bleeding may be advisable during coadministration of dipyridamole and oral anticoagulants. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Dipyridamole Oral, Intravenous

Generic Name: dipyridamole

Brand name: Persantine, Persantine IV

Synonyms: Dipyridamole

What is Dipyridamole Oral, Intravenous?