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Coumadin and Equetro

Determining the interaction of Coumadin and Equetro and the possibility of their joint administration.

Check result:

Coumadin <> Equetro

Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine with warfarin may make your warfarin less effective. You may need a dose adjustment based on your prothrombin time or International Normalized Ratio (INR). You should notify your doctor if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Carbamazepine may induce the metabolism of warfarin and reduce its anticoagulant effect. The mechanism is induction of hepatic isoenzyme metabolism by carbamazepine. Carbamazepine may interact with other oral anticoagulants in a similar fashion.

MANAGEMENT: INR should be monitored whenever carbamazepine is started or discontinued in a patient receiving an oral anticoagulant. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

References

Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
Kendall AG, Boivin M "Warfarin-carbamazepine interaction." Ann Intern Med 94 (1981): 280
Massey EW "Effect of carbamazepine on coumadin metabolism." Ann Neurol 13 (1983): 691-2
Denbow CE, Frazer HS "Clinically significant hemorrhage due to warfarin-carbamazepine interaction." South Med J 83 (1990): 981
Ross JR, Beeley L "Interaction between carbamazepine and warfarin." Br Med J 280 (1980): 1415-6
Hansen JM, Siersboek-Nielsen K, Skovsted L "Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man." Clin Pharmacol Ther 12 (1971): 539-43
Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Equetro?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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