Coumadin and Gemzar

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with gemcitabine can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Gemcitabine may alter the pharmacodynamic response to warfarin resulting in an increased INR and risk of bleeding. The mechanism has not been fully determined. It has been suggested that warfarin metabolism or the synthesis of clotting factors may be decreased due to reversible hepatotoxicity induced by gemcitabine. Other anticoagulants may also be affected, although clinical data are lacking.

MANAGEMENT: Increased frequency of clinical monitoring of INR and liver function tests is recommended. Patients should be advised to promptly report any signs of unusual bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, bruising, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Gemzar

Generic Name: gemcitabine

Brand name: Gemzar, Infugem

Synonyms: n.a.

What is Gemzar?