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Coumadin and Harvoni

Determining the interaction of Coumadin and Harvoni and the possibility of their joint administration.

Check result:

Coumadin <> Harvoni

Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Sofosbuvir may alter the effects of warfarin. You may need more frequent monitoring of your prothrombin time or INR by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience unusual bleeding or bruising. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Liver function changes due to treatment with direct-acting HCV antiviral agents may affect the therapeutic efficacy of vitamin K antagonists. The mechanism may involve potential pharmacokinetic changes for some vitamin K antagonists due to altered metabolism, or patients may exhibit alterations in hepatic synthesis of vitamin K-dependent coagulation factors and clearance of activated factors that could impact response to vitamin K antagonists. Pharmacokinetic studies conducted with simeprevir and also with ombitasvir/paritaprevir/ritonavir (with or without dasabuvir) have reported no significant effects on the plasma levels of warfarin, and no dosage adjustments are recommended for warfarin when used with these agents. However, pharmacokinetic data are not available for other direct-acting HCV antiviral agent and vitamin K antagonist combinations.

MANAGEMENT: The INR should be monitored more closely following initiation or discontinuation of a direct-acting HCV antiviral agent, and the dosage of vitamin K antagonist adjusted if necessary.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
"Product Information. Incivek (telaprevir)." Vertex Pharmaceuticals, Cambridge, MA.
Cerner Multum, Inc. "Australian Product Information." O 0
Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
"Product Information. Victrelis (boceprevir)." Schering-Plough Corporation, Kenilworth, NJ.
"Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals, Titusville, NJ.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Harvoni

Generic Name: ledipasvir / sofosbuvir

Brand name: Harvoni

Synonyms: n.a.

What is Harvoni?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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