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Coumadin and Neo-Rx

Determining the interaction of Coumadin and Neo-Rx and the possibility of their joint administration.

Check result:

Coumadin <> Neo-Rx

Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using warfarin together with neomycin can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that the effect of oral anticoagulants may be increased in patients also receiving oral neomycin. Increases in INR are possible. The exact mechanism is unknown but may involve depletion of certain clotting factors due to suppression of vitamin K-producing intestinal flora and inhibition of vitamin K absorption. Clinical data have been conflicting. Significant changes are not expected in patients with normal dietary intake of vitamin K.

MANAGEMENT: The clinician may consider closer INR and clinical monitoring in patients starting or stopping neomycin therapy while also receiving oral anticoagulants. The dose of the oral anticoagulant may need to be adjusted. Patients should be advised to promptly report any signs of bleeding to their doctor, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Multum Information Services, Inc. Expert Review Panel"

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Neo-Rx

Generic Name: neomycin

Brand name: Neo-Fradin, Neo-Tab, Mycifradin

Synonyms: Neomycin

What is Neo-Rx?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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