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Coumadin and Oleptro Oral

Determining the interaction of Coumadin and Oleptro Oral and the possibility of their joint administration.

Check result:
Coumadin <> Oleptro Oral
Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One case report has suggested that trazodone may reduce prothrombin and partial thromboplastin times. The mechanism and clinical significance are unknown. Similar effects may occur with other oral anticoagulants. The patient's PT or INR should be observed for alterations. An increase in oral anticoagulant dosage may be necessary. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

References
  • Hardy JL, Sirois A "Reduction of prothrombin and partial thromboplastin times with trazodone." Can Med Assoc J 135 (1986): 1372
Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

Oleptro Oral

Generic Name: trazodone

Brand name: Oleptro, Desyrel, Desyrel Dividose

Synonyms: Oleptro

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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