Coumadin and Pioglitazone and Glimepiride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with glimepiride may increase the effects of glimepiride on lowering blood sugar. This could cause your blood sugar levels to get too low. Signs of low blood sugar include headache, hunger, weakness, dizziness, drowsiness, nervousness, sweating, confusion, and tremor. Talk with your doctor before using warfarin together with glimepiride. You may need a dose adjustment or need to check your blood sugar more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The hypoglycemic action of glimepiride may be potentiated by highly protein-bound drugs. The mechanism is displacement of glimepiride from protein-binding sites, resulting in higher plasma concentrations of unbound glimepiride available to act on pancreatic beta cells.

MANAGEMENT: Patients should be monitored closely for hypoglycemia during concomitant therapy, particularly following addition of a highly protein-bound drug to a stabilized glimepiride regimen. Patients should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. Likewise, such patients should be observed for loss of glycemic control when the highly protein-bound drug is withdrawn.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Pioglitazone and Glimepiride

Generic Name: glimepiride / pioglitazone

Brand name: Duetact

Synonyms: Glimepiride and pioglitazone

What is Pioglitazone and Glimepiride?