Drug search by name

Coumadin and Pletal

Determining the interaction of Coumadin and Pletal and the possibility of their joint administration.

Check result:

Coumadin <> Pletal

Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cilostazol 100 mg twice daily for 7 or 13 days did not significantly affect the pharmacokinetics of single doses of warfarin 25 mg in healthy subjects. Activated partial thromboplastin time, prothrombin time, Ivy bleeding time, and platelet aggregation also did not change. There are no data on the effects of concomitant multiple dosing.

References

Tata PN, Millikaarjun S, Bramer SL "Plasma protein binding studies of warfarin and its displacement interaction with cilostazol." Pharm Res 14(11 Suppl) (1997): S-555
Mallikaarjun S, Bramer SL "Effect of cilostazol on the pharmacokinetics and pharmacodynamics of warfarin." Clin Pharmacokinet 37 (1999): 79-86
Millakaarjun S, Mico BA, Forbes WP, Bramer SL "A pharmacokinetic and pharmacodynamic study of the potential interaction between cilostazol and warfarin." Pharm Res 14(11 Suppl) (1997): S-555
"Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals, Rockville, MD.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Pletal

Generic Name: cilostazol

Brand name: Pletal

Synonyms: n.a.

What is Pletal?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions