Coumadin and Pms-Isoniazid

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with isoniazid can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Isoniazid may increase the anticoagulant effect of warfarin, perhaps by inhibition of warfarin metabolism. This effect has been reported with an isoniazid dose of 600 mg per day. Other oral anticoagulants may interact with isoniazid in a similar fashion. The proposed mechanism is inhibition of CYP450 2C9 hepatic metabolism by isoniazid.

MANAGEMENT: The patient's INR should be monitored, and the anticoagulant dosage should be adjusted if necessary, whenever isoniazid is initiated, discontinued or the dosage is changed. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bruising, red or brown urine, or red or black stools.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Pms-Isoniazid

Generic Name: isoniazid

Brand name: Nydrazid

Synonyms: Isoniazid

What is Pms-Isoniazid?