Coumadin and Topamax (Topiramate Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Coadministration with topiramate may decrease the anticoagulant effects of vitamin K antagonists (VKAs). The mechanism has not been delineated. MANAGEMENT: Until more information is available, patients receiving VKAs with topiramate should be closely monitored during concomitant therapy. The prothrombin time (PT) or International Normalized Ratio (INR) should be checked frequently and the VKA dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of topiramate therapy. References Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

MONITOR: Coadministration with topiramate may decrease the anticoagulant effects of vitamin K antagonists (VKAs). The mechanism has not been delineated.

MANAGEMENT: Until more information is available, patients receiving VKAs with topiramate should be closely monitored during concomitant therapy. The prothrombin time (PT) or International Normalized Ratio (INR) should be checked frequently and the VKA dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of topiramate therapy.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Topamax (Topiramate Tablets)

Generic Name: topiramate

Brand name: Qudexy XR, Topamax, Topamax Sprinkle, Topiragen, Trokendi XR, Qudexy XR Sprinkle

Synonyms: Topamax

What is Topamax (Topiramate Tablets)?