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Coumadin and Vorapaxar

Determining the interaction of Coumadin and Vorapaxar and the possibility of their joint administration.

Check result:
Coumadin <> Vorapaxar
Relevance: 01.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using vorapaxar together with warfarin may increase the risk of bleeding, including severe and sometimes fatal hemorrhage. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration of vorapaxar with other agents that affect hemostasis such as anticoagulants may increase the risk of bleeding complications, including intracranial hemorrhage and fatal bleeding.

MANAGEMENT: Concomitant use of vorapaxar with warfarin or other anticoagulants should generally be avoided.

References
  • "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.
Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

Vorapaxar

Generic Name: vorapaxar

Brand name: Zontivity

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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