Coumadin and Zetia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

In a study of 12 healthy adult males, coadministration of ezetimibe (10 mg once daily) had no significant effect on the bioavailability of warfarin or prothrombin time. Increased International Normalized Ratio (INR) has been reported during postmarketing use of ezetimibe in patients who had it added to warfarin. However, most of these patients were also on other medications, so the relationship to ezetimibe is uncertain. Ezetimibe product labeling recommends that the INR be appropriately monitored if ezetimibe is used in patients receiving warfarin. The effect of ezetimibe on other oral anticoagulants is unknown.

Coumadin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Coumadin?

Zetia

Generic Name: ezetimibe

Brand name: Zetia

Synonyms: n.a.

What is Zetia?