Coumadin Injection and Dexmethylphenidate Extended-Release Capsules
Determining the interaction of Coumadin Injection and Dexmethylphenidate Extended-Release Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Data from an early study involving four subjects suggest that the coadministration with methylphenidate may prolong the half-life of ethyl biscoumacetate (a coumarin anticoagulant), presumably due to inhibition of its metabolism in the liver. However, a subsequent study of 12 healthy volunteers found little or no effect on ethyl biscoumacetate half-life or prothrombin time. Thus, available evidence does not seem to support a clinically significant drug interaction. Nevertheless, it may be appropriate to monitor the pharmacologic response to coumarin anticoagulants and the International Normalization Ratio (INR) more closely whenever methylphenidate (racemic) or dexmethylphenidate (the more pharmacologically active d-enantiomer) is added to or withdrawn from therapy, and the anticoagulant dosage adjusted as necessary. Patients should be advised to notify their physician if they experience any signs of excessive anticoagulation such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.
- "Product Information. Focalin (dexmethylphenidate)." Mikart Inc, Atlanta, GA.
- "Product Information. Ritalin (methylphenidate)." Novartis Pharmaceuticals, East Hanover, NJ.
- Hague DE, Smith ME, Ryan JR, McMahan FG "The effect of methylphenidate and prolintane on the metabolism of ethyl biscoumacetate." Clin Pharmacol Ther 12 (1971): 259-62
- Garrettson LK, Perel JM, Dayton PG "Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate." JAMA 207 (1969): 1053-6
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: dexmethylphenidate
Brand name: Focalin, Focalin XR
Synonyms: Dexmethylphenidate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Dexmethylphenidate Hydrochloride
- Coumadin Injection-Dexmethylphenidate Tablets
- Coumadin Injection-DexPak
- Coumadin Injection-DexPak 10 Day Taperpak
- Coumadin Injection-DexPak 13 DayTaperpak
- Coumadin Injection-DexPak 6 DayTaperpak
- Dexmethylphenidate Extended-Release Capsules-Covaryx
- Dexmethylphenidate Extended-Release Capsules-Covaryx HS
- Dexmethylphenidate Extended-Release Capsules-Covera-HS
- Dexmethylphenidate Extended-Release Capsules-Cozaar
- Dexmethylphenidate Extended-Release Capsules-CPB WC
- Dexmethylphenidate Extended-Release Capsules-CPM-PSE DM Drops