Coumadin Injection and Elbasvir and grazoprevir
Determining the interaction of Coumadin Injection and Elbasvir and grazoprevir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Elbasvir may alter the effects of warfarin. You may need more frequent monitoring of your prothrombin time or INR by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience unusual bleeding or bruising. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Liver function changes due to treatment with direct-acting HCV antiviral agents may affect the therapeutic efficacy of vitamin K antagonists. The mechanism may involve potential pharmacokinetic changes for some vitamin K antagonists due to altered metabolism, or patients may exhibit alterations in hepatic synthesis of vitamin K-dependent coagulation factors and clearance of activated factors that could impact response to vitamin K antagonists. Pharmacokinetic studies conducted with simeprevir and also with ombitasvir/paritaprevir/ritonavir (with or without dasabuvir) have reported no significant effects on the plasma levels of warfarin, and no dosage adjustments are recommended for warfarin when used with these agents. However, pharmacokinetic data are not available for other direct-acting HCV antiviral agent and vitamin K antagonist combinations.
MANAGEMENT: The INR should be monitored more closely following initiation or discontinuation of a direct-acting HCV antiviral agent, and the dosage of vitamin K antagonist adjusted if necessary.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- "Product Information. Incivek (telaprevir)." Vertex Pharmaceuticals, Cambridge, MA.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- "Product Information. Victrelis (boceprevir)." Schering-Plough Corporation, Kenilworth, NJ.
- "Product Information. Olysio (simeprevir)." Janssen Pharmaceuticals, Titusville, NJ.
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: elbasvir / grazoprevir
Brand name: Zepatier
Synonyms: Elbasvir and Grazoprevir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Eldepryl
- Coumadin Injection-Eldepryl Capsules
- Coumadin Injection-Eldepryl Oral
- Coumadin Injection-Eldepryl Tablets
- Coumadin Injection-ELenzaPatch
- Coumadin Injection-Elepsia XR
- Elbasvir and grazoprevir-Covaryx
- Elbasvir and grazoprevir-Covaryx HS
- Elbasvir and grazoprevir-Covera-HS
- Elbasvir and grazoprevir-Cozaar
- Elbasvir and grazoprevir-CPB WC
- Elbasvir and grazoprevir-CPM-PSE DM Drops