Coumadin Injection and Ethacrynic acid
Determining the interaction of Coumadin Injection and Ethacrynic acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some loop diuretics may displace warfarin or other oral anticoagulants from plasma protein binding sites. Plasma warfarin concentrations and warfarin effects may be increased. Data are available for furosemide and ethacrynic acid only. This interaction appears to be of minor clinical importance. Close monitoring of the INR is recommended, particularly if diuretic dosage must be high. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (second of two parts)." N Engl J Med 285 (1971): 547-58
- Petrick RJ, Kronacher N, Alcena V "Interaction between warfarin and ethacrynic acid." JAMA 231 (1975): 843-4
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: ethacrynic acid
Brand name: Edecrin, Edecrin Sodium, Sodium Edecrin
Synonyms: Ethacrynic Acid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Ethacrynic Acid Injection
- Coumadin Injection-Ethacrynic Acid Tablets
- Coumadin Injection-Ethacrynic Sodium
- Coumadin Injection-Ethacrynic Sodium Injection
- Coumadin Injection-Ethambutol
- Coumadin Injection-Ethambutol Hydrochloride
- Ethacrynic acid-Covaryx
- Ethacrynic acid-Covaryx HS
- Ethacrynic acid-Covera-HS
- Ethacrynic acid-Cozaar
- Ethacrynic acid-CPB WC
- Ethacrynic acid-CPM-PSE DM Drops