Coumadin Injection and Flutamide
Determining the interaction of Coumadin Injection and Flutamide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using flutamide together with warfarin can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Flutamide may enhance the hypoprothrombinemic response to warfarin by an unknown mechanism. In patients stabilized on warfarin, elevations in prothrombin time have been reported with the addition of flutamide to the drug regimen.
MANAGEMENT: Patients should be monitored for altered anticoagulation and advised to report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, nosebleeds, bleeding of gums from brushing, bruising, red or brown urine, or red or black stools.
- "Product Information. Eulexin (flutamide)." Schering Laboratories, Kenilworth, NJ.
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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