Coumadin Injection and Gemcitabine Intravenous
Determining the interaction of Coumadin Injection and Gemcitabine Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using warfarin together with gemcitabine can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Gemcitabine may alter the pharmacodynamic response to warfarin resulting in an increased INR and risk of bleeding. The mechanism has not been fully determined. It has been suggested that warfarin metabolism or the synthesis of clotting factors may be decreased due to reversible hepatotoxicity induced by gemcitabine. Other anticoagulants may also be affected, although clinical data are lacking.
MANAGEMENT: Increased frequency of clinical monitoring of INR and liver function tests is recommended. Patients should be advised to promptly report any signs of unusual bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, bruising, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, red or brown urine, or red or black stools.
- Kinikar SA, Kolesar JM "Identification of a gemcitabine-warfarin interaction." Pharmacotherapy 19 (1999): 1331-3
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: gemcitabine
Brand name: Gemzar, Infugem
Synonyms: Gemcitabine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Gemfibrozil
- Coumadin Injection-Gemifloxacin
- Coumadin Injection-Gemifloxacin Mesylate
- Coumadin Injection-Gemtuzumab Intravenous
- Coumadin Injection-Gemtuzumab ozogamicin
- Coumadin Injection-Gemzar
- Gemcitabine Intravenous-Covaryx
- Gemcitabine Intravenous-Covaryx HS
- Gemcitabine Intravenous-Covera-HS
- Gemcitabine Intravenous-Cozaar
- Gemcitabine Intravenous-CPB WC
- Gemcitabine Intravenous-CPM-PSE DM Drops