Coumadin Injection and Intelence
Determining the interaction of Coumadin Injection and Intelence and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using warfarin together with etravirine can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with etravirine may increase the plasma concentrations of warfarin. The proposed mechanism is etravirine inhibition of CYP450 2C19 and 2C9, the isoenzymes responsible for the metabolic clearance of the R(+) and S(-) enantiomers of warfarin, respectively.
MANAGEMENT: Given the potential for interaction and the high degree of interpatient variability with respect to warfarin metabolism, patients should be closely monitored during concomitant therapy with etravirine. The INR should be checked frequently and warfarin dosage adjusted accordingly, particularly following initiation or discontinuation of etravirine in patients who are stabilized on their warfarin regimen. The same precaution may be applicable during therapy with other oral anticoagulants, although clinical and pharmacokinetic data are lacking. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
- "Product Information. Intelence (etravirine)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Interferon alfa-2b
- Coumadin Injection-Interferon alfa-2b Injection
- Coumadin Injection-Interferon Alfa-2b Injection Solution
- Coumadin Injection-Interferon Alfa-2b Powder for Injection
- Coumadin Injection-Interferon Alfa-2b Prefilled Pens
- Coumadin Injection-Interferon alfa-n3
- Intelence-Covaryx
- Intelence-Covaryx HS
- Intelence-Covera-HS
- Intelence-Cozaar
- Intelence-CPB WC
- Intelence-CPM-PSE DM Drops