Coumadin Injection and Levodopa, Carbidopa, and Entacapone
Determining the interaction of Coumadin Injection and Levodopa, Carbidopa, and Entacapone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with entacapone has been shown to slightly increase plasma concentrations of the less pharmacologically active R-enantiomer of warfarin. The mechanism of interaction is unknown. In a study of 12 healthy subjects, entacapone (200 mg orally four times a day for 1 week) increased the mean steady-state area under the plasma concentration-time curve (AUC) of R-warfarin by 18% compared to placebo. Other pharmacokinetic parameters of R-warfarin, as well as pharmacokinetics of S-warfarin, were not significantly affected. Entacapone increased the INR by an average of 13% relative to placebo, although safety and tolerability variables were not different between treatment phases. These changes are unlikely to be of clinical significance.
- Dingemanse J, Meyerhoff C, Schadrack J "Effect of the catechol-O-methyltransferase inhibitor entacapone on the steady-state pharmacokinetics and pharmacodynamics of warfarin." Br J Clin Pharmacol 53 (2002): 485-91
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: carbidopa / entacapone / levodopa
Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo
Synonyms: Carbidopa, entacapone, and levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Levodopa/Carbidopa
- Coumadin Injection-Levofloxacin
- Coumadin Injection-Levofloxacin (Systemic)
- Coumadin Injection-Levofloxacin injection
- Coumadin Injection-Levofloxacin Injection Concentrate
- Coumadin Injection-Levofloxacin Intravenous
- Levodopa, Carbidopa, and Entacapone-Covaryx
- Levodopa, Carbidopa, and Entacapone-Covaryx HS
- Levodopa, Carbidopa, and Entacapone-Covera-HS
- Levodopa, Carbidopa, and Entacapone-Cozaar
- Levodopa, Carbidopa, and Entacapone-CPB WC
- Levodopa, Carbidopa, and Entacapone-CPM-PSE DM Drops