Coumadin Injection and Lixisenatide Subcutaneous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration of a single 25 mg dose of warfarin with daily dosing of lixisenatide 20 mcg resulted in a 19% decrease in warfarin peak plasma concentration (Cmax) and a 7-hour delay in time to reach peak plasma concentration (Tmax), but had no effect on warfarin systemic exposure (AUC) or the International Normalized Ratio (INR). The mechanism of interaction may involve delayed absorption due to slowing of the gastric emptying rate by lixisenatide. Based on these observations, no dosage adjustment for warfarin is required when coadministered with lixisenatide. The interaction has not been studied with other oral vitamin K antagonists.

Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?

Lixisenatide Subcutaneous

Generic Name: lixisenatide

Brand name: Adlyxin

Synonyms: Lixisenatide

What is Lixisenatide Subcutaneous?