Coumadin Injection and Mesnex Injection
Determining the interaction of Coumadin Injection and Mesnex Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using warfarin together with mesna can decrease the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.
Professional:MONITOR: Limited data (from three patients) reveal enhanced anticoagulant activity (significantly increased INR) during chemotherapy with ifosfamide/mesna in patients previously stable on warfarin. The mechanism is not known, but is suspected to be displacement of warfarin from protein-binding sites by ifosfamide metabolites.
MANAGEMENT: Careful and frequent monitoring of INR during coadministration is recommended. Also, close monitoring is recommended when chemotherapeutic agents are discontinued, because anticoagulant effect may be decreased and the risk of thromboembolism increased. It may also be advisable to monitor patients on other anticoagulants.
- Hall G, Lind MJ, Huang M, Moore A, Gane A, Roberts JT, Cantwell BM "Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control." Postgrad Med J 66 (1990): 860-1
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: mesna
Brand name: Mesnex
Synonyms: Mesnex (oral/injection), Mesnex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Mesnex Oral
- Coumadin Injection-Mesnex oral/injection
- Coumadin Injection-Mestinon
- Coumadin Injection-Mestinon (Pyridostigmine Extended-Release Tablets)
- Coumadin Injection-Mestinon (Pyridostigmine Liquid)
- Coumadin Injection-Mestinon (Pyridostigmine Tablets)
- Mesnex Injection-Covaryx
- Mesnex Injection-Covaryx HS
- Mesnex Injection-Covera-HS
- Mesnex Injection-Cozaar
- Mesnex Injection-CPB WC
- Mesnex Injection-CPM-PSE DM Drops