Coumadin Injection and Neoral Oral
Determining the interaction of Coumadin Injection and Neoral Oral and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using warfarin together with cycloSPORINE may alter the effects of both medications. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: A few case reports have suggested that the concomitant use of cyclosporine and warfarin may result in both increased and reduced effects of both agents, although this interaction is not well established. The mechanism is unknown. A similar reaction may occur with other oral coumarin anticoagulants.
MANAGEMENT: It may be advisable to monitor prothrombin time (PT) and/or International Normalized Ratio(INR), as well as cyclosporine blood concentrations and the patient's response is recommended if these agents are used together.
- Cockburn I "Cyclosporine A: a clinical evaluation of drug interactions." Transplant Proc 18 (1986): 50-5
- Snyder DS "Interaction between cyclosporine and warfarin." Ann Intern Med 108 (1988): 311
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Neoral (Capsules, Modified), Neoral
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Neosar
- Coumadin Injection-Neosporin + Pain Relief Ointment
- Coumadin Injection-Neosporin AF Topical
- Coumadin Injection-Neosporin G.U
- Coumadin Injection-Neosporin G.U. Irrigant [DSC}
- Coumadin Injection-Neosporin Original
- Neoral Oral-Covaryx
- Neoral Oral-Covaryx HS
- Neoral Oral-Covera-HS
- Neoral Oral-Cozaar
- Neoral Oral-CPB WC
- Neoral Oral-CPM-PSE DM Drops