Coumadin Injection and Otrexup injection
Determining the interaction of Coumadin Injection and Otrexup injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:A case report describes a 62-year-old man treated with warfarin whose prothrombin times increased by 50% to 100% during three cycles of a chemotherapeutic regimen consisting of cyclophosphamide, doxorubicin, etoposide, mechlorethamine, vincristine, procarbazine, methotrexate, and prednisone. He developed a subconjunctival hemorrhage on day 1 of the first cycle. The prothrombin time returned to normal within one week of discontinuation of warfarin. Due to the complexity of the chemotherapeutic regimen, a causal relationship to any of the medications or combination of medications cannot be established.
- Seifter EJ, Brooks BJ, Urba WJ "Possible interactions between warfarin and antineoplastic drugs." Cancer Treat Rep 69 (1985): 244-5
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: methotrexate
Brand name: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep
Synonyms: Otrexup (injection), Otrexup
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Outgro
- Coumadin Injection-Ovcon 35
- Coumadin Injection-Ovidrel
- Coumadin Injection-Ovidrel injectable
- Coumadin Injection-Ovidrel Injection
- Coumadin Injection-Ovol
- Otrexup injection-Covaryx
- Otrexup injection-Covaryx HS
- Otrexup injection-Covera-HS
- Otrexup injection-Cozaar
- Otrexup injection-CPB WC
- Otrexup injection-CPM-PSE DM Drops